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This handbook is for laboratories that provide an NHS newborn blood spot screening service for CHT in the UK.It provides information and guidelines to support screening laboratories, including:

• the CHT screening protocol
• details of the revised thyroid stimulating hormone (TSH) cut-off value introduced in April 2018
• the CHT preterm repeat policy
• laboratory quality assessment procedures
• the process for communicating results
• programme standards and data collection

This publication was previously published by Public Health England, which closed on 30 September 2021.